India Hospital Tour by We Care India Medical tourism Company Surgery and Treatment in India by We Care India, Mumbai, Delhi, Chennai, Bangalore Surgery and Treatment in India at Low Cost JCI / ISO accredited hospital and experienced surgeon advantages
Medical tourism by We Care India for Low Cost Surgery and Treatment  at Hospitals in India
Wecare Health Services Live Support

Your healthcare is now our concerns. 24x7 Online Hospitality Service.
Call: +91 9029304141 (10 am. To 8 pm. IST)
Post an EnquiryMedical Quote, Free No Obligation for Medical tourism Patients in India( Preferred )
(Only for international patients seeking treatment in India)
Only in India Hospital Tour
     
Treatment & Surgery
Nephrology (Kidney)
Treatments Available
Amyloidosis
Bladder Outlet Incision    Surgery
Cystoscopy Surgery
Cysto-Diathermy Surgery
Diabetic Kidney Disorder
Electrolyte Disorders
Glomerulonephritis
Lupus Nephritis
Nephrotic Syndrome
Nephrectomy Surgery
Polycystic Kidney Disorder
Pyelonephritis
Removal Of Kidney Stone    Surgery
Renal Failure Treatment
Renal Hypertension
Renal Insufficiency
Retrograde Pyelogram    Surgery
Ureterolithotomy -Dormia    Basket Surgery
Urethroscopy Surgery
Cost Guide
Nephrology Hospitals
Nephrology Doctors
 

Amyloidosis Treatment

Bookmark and Share Go Back Print This Page Add to Favorites
|
Home > Nephrology > Amyloidosis Treatment

Overview

Amyloidosis - Treatment in India

What is amyloidosis?

Amyloidosis is a group of diseases that result from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area and may not be harmful or only affect a single tissue of the body. This form of amyloidosis is called localized amyloidosis. Amyloidosis that affects tissues throughout the body is referred to as systemic amyloidosis. Systemic amyloidosis can cause serious changes in virtually any organ of the body.

Amyloidosis can occur as its own entity or "secondarily" as a result of another illness, including multiple myeloma, chronic infections (such as tuberculosis or osteomyelitis), or chronic inflammatory diseases (such as rheumatoid arthritis and ankylosing spondylitis). Amyloidosis can also be localized to a specific body area from aging. This localized form of amyloidosis does not have systemic implications for the rest of the body. The protein that deposits in the brain of patients with Alzheimer's disease is a form of amyloid.

Systemic amyloidosis has been classified into three major types that are very different from each other. These are distinguished by a two-letter code that begins with an A (for amyloid). The second letter of the code stands for the protein that accumulates in the tissues in that particular type of amyloidosis. The types of systemic amyloidosis are currently categorized as primary (AL), secondary (AA), and hereditary (ATTR).

In addition, other forms of amyloidosis include beta-2 microglobulin amyloidosis and localized amyloidoses.


Primary amyloidosis

Primary amyloidosis, or AL, occurs when a specialized cell in the bone marrow (plasma cell) spontaneously overproduces a particular protein portion of an antibody called the light chain. (This is why it is coded as AL.) The deposits in the tissues of people with primary amyloidosis are AL proteins. Primary amyloidosis can occur with a bone marrow cancer of plasma cells called multiple myeloma.

Primary amyloid is not associated with any other diseases but is a disease entity of its own, conventionally requiring chemotherapy treatment. Researchers at the Mayo Clinic in Rochester, Minnesota, and Boston University in Boston, Massachusetts, have demonstrated benefits from stem-cell transplantation, harvesting patients' own stem cells to treat primary amyloidosis.

^ Back to Top

Secondary amyloidosis

When amyloidosis occurs "secondarily" as a result of another illness, such as multiple myeloma, chronic infections (for example, tuberculosis or osteomyelitis), or chronic inflammatory diseases (for example, rheumatoid arthritis and ankylosing spondylitis), the condition is referred to as secondary amyloidosis or AA. The amyloid tissue deposits in secondary amyloidosis are AA proteins. The treatment of patients' secondary amyloidosis is directed at treating the underlying illness in that particular patient.


Familial amyloidosis

Familial amyloidosis, or ATTR, is a rare form of inherited amyloidosis. The amyloid deposits in familial amyloidosis are composed of the protein transthyretin, or TTR, which is made in the liver. Familial amyloidosis is an inherited autosomal dominant in genetics terminology. This means that for the offspring of a person with the condition, there is a 50% chance of inheriting it.


Beta-2 microglobulin amyloidosis

Beta-2 microglobulin amyloidosis occurs when amyloid deposits develop in patients on dialysis with longstanding kidney failure. The amyloid deposits are composed of beta-2 microglobulin protein and are often found around joints.


Localized amyloidoses

The many forms of localized amyloidosis are a result of amyloid deposits in specific areas of the body and are distinct from systemic forms of amyloidosis that deposit amyloid throughout the body. Localized amyloid deposits occur in the brain from Alzheimer's disease. In various tissues, often with aging, amyloid can be locally produced and deposited to cause tissue injury.

^ Back to Top

What are symptoms of amyloidosis?

Symptoms in patients with amyloidosis result from abnormal functioning of the particular organs involved. The heart, kidneys, liver, bowels, skin, nerves, joints, and lungs can be affected. As a result, symptoms are vague and can include fatigue, shortness of breath, weight loss, lack of appetite, numbness, tingling, weakness, enlarged tongue, and swelling. Amyloidosis affecting the kidney leads to "nephrotic syndrome," which is characterized by severe loss of protein in the urine and swelling of the extremities.

Amyloidosis Treatment India Offers info on Cost Amyloidosis Surgeons Hospital India, Amyloidosis Treatment India
[ Amyloid may build up in the wrist and cause bone cysts or carpal tunnel syndrome. ]



How is amyloidosis diagnosed?

The diagnosis of amyloidosis is made by detecting the characteristic amyloid protein in a biopsy specimen of involved tissue (such as mouth, rectum, fat, kidney, heart, or liver). A needle aspiration biopsy of fat just under the skin of the belly (fat pad aspiration), originally developed at Boston University, offers a simple and less invasive method to diagnose systemic amyloidosis. Pathologists can see the protein in the biopsy specimen when it is coated with a special dye, called Congo red stain.

^ Back to Top

How is amyloidosis treated?

Initial treatment of amyloidosis involves correcting organ failure and treating any underlying illness (such as myeloma, infection, or inflammation). The disease is frequently discovered after significant organ damage has already occurred. Therefore, stabilization of organ function is an initial target of treatment. The most frequent cause of death in systemic amyloidosis is kidney failure.

Sephardic Jews and Turks inherit a genetic disease called Familial Mediterranean Fever, which is associated with amyloidosis and characterized by episodes of "attacks" of fever, joint, and abdominal pains. These attacks can be prevented with the medication colchicine. Armenians and Ashkenazi Jews also have a higher incidence of Familial Mediterranean Fever attacks but do not suffer amyloid deposition disease. Other reports of amyloidosis in families are extremely rare.

Researchers are currently enrolling patients with primary amyloidosis in clinical trials using a cancer chemotherapy medication (melphalan [Alkeran]), in conjunction with bone-marrow stem-cells transplantation. The results have been promising, and this combination treatment is offered to eradicate the amyloidosis in selected patients, provided that the underlying medical condition of the patient is adequate. These aggressive treatment options with stem-cell transplantation and high doses of chemotherapy are a true breakthrough in the treatment of these patients.

Familial amyloidosis can now be cured with liver transplantation. This option requires an accurate diagnosis of the specific protein that causes the disease.


Amyloidosis At A Glance

  • Amyloidosis is a disorder resulting from abnormal protein (amyloid) deposits in body tissues.
  • Amyloidosis can occur as an isolated disease or as a result of another illness.
  • Symptoms in patients with amyloidosis result from abnormal functioning of the particular organs involved.
  • Diagnosis of amyloidosis is made with a biopsy of involved tissue.
  • Treatment options for amyloidosis depends on the type of amyloidosis and involves correcting organ failure and treating any underlying conditions.





The list of of Nephrology Hospitals in India is as follows : -


Apollo Hospitals Bangalore Apollo Hospitals, Bangalore, India
Apollo Hospital Chennai Apollo Hospital, Chennai, India
Apollo Hospitals Hyderabad Apollo Hospitals, Hyderabad, India
Apollo Hospitals Delhi Indraprastha Apollo Hospital, Delhi, India
Apollo Hospitals Kolkata Apollo Gleneagles Hospital, Kolkata, India
Apollo Hospital, Goa, India Apollo Hospital, Goa, India
Wockhardt Hospital Bangalore India Wockhardt Hospital, Bangalore India
Wockhardt Hospital hyderabad, India Wockhardt Hospital, hyderabad, India
Wockhardt Hospital Mumbai, India Wockhardt Hospital, Mumbai, India
Wockhardt Hospital and Kidney Institute, Kolkata, India Wockhardt Hospital and Kidney Institute, Kolkata, India
Fortis Hospital, Delhi, India Fortis Hospital, Delhi, India
Fortis Hospital Mohali, India Fortis Hospital, Mohali, India
Fortis Hospital Noida, India Fortis Hospital, Noida, India
Manipal Hospital, Bangalore, India Manipal Hospital, Bangalore, India
Artemis Hospital, Gurgaon ( Delhi ) , India Artemis Hospital, Gurgaon ( Delhi ) , India
Max Super Specialty hospital,  Delhi, India Max Super Specialty hospital, Delhi, India
BGS Global Hospital Bangalore, India BGS Global Hospital, Bangalore, India
BGS Global Hospital Chennai, India BGS Global Hospital, Chennai, India
BGS Global Hospital Hyderabad, India BGS Global Hospital, Hyderabad, India


^ Back to Top

For more information, medical assessment and medical quote send your detailed medical history and medical reports
as email attachment to
Email : - info@wecareindia.com
Call: +91 9029304141 (10 am. To 8 pm. IST)
(Only for international patients seeking treatment in India)

 
Send Response
 

Gender : Age :




  

For a detailed evaluation send patient’s medical reports / X rays / doctors notes to info@wecareindia.com
 
Patient Story

Patient Storys

Successful heart surgery at We Care India partner hospital allows Robert Clarke to live a normal life despite a rare genetic disorder We Care india helped Robert find best super specialised surgeon for his rare conditions.

Read    : Robert's Story
See All : Patient's Success Stories

Related Link

Group Websites


Find us on

 
Medical Tourism Search Information For Professionals Resources
Hospitals By :

 

 
 
Neurosurgery, Brain Surgery, Epilepsy Surgery, Brain Tumor Surgery in India

SSL Certificate
Neurosurgery, Heart surgery, Brain Surgery , Brain Tumor Surgery in India
   
 

Copyright © 2009 - 2010 We Care India. All Rights Reserved.
Home | About Us | Site Map | Get a Quote | Disclaimer | Advertise With Us | Contact Us

 

Amyloidosis Treatment India Offers info on Cost Amyloidosis Surgeons Hospital India, Amyloidosis Treatment India, Cost Amyloidosis Surgery India, Amyloidosis Treatment India, Low Cost Amyloidosis Treatment Delhi India, Amyloidosis Treatment Hospital Delhi India, Useful information on Amyloidosis India, Amyloidosis Symptoms India, Amyloidosis Types India, Amyloidosis Treatment Mumbai Hospital India, Cost Amyloidosis Surgery Mumbai India, Affordable Amyloidosis Hospital India, Amyloidosis India, Amyloidosis Symptoms India, Types Of Amyloidosis India, Treatment Of Amyloidosis India, Amyloidosis Surgery - India Hospital Tour