If suitable, many cancers caught in the early stages of development, which conventionally would either be removed or treated with radiotherapy and or anticancer drugs, can now be treated with HIFU
Malignancies
Breast cancer
As a non-invasive modality, high intensity focused ultrasound (HIFU) ablation is receiving increasing interest for the local treatment of solid malignancies. The principle of this technique is that a high-energy ultrasound (US) beam can be focused at a distance from the radiating surface of transducer. The energy within the focal region can be sufficient to cook tissue and to induce necrosis of targets such as tumors, without causing damage to overlying or surrounding vital structures. The ability to cause cell death in a volume of tissue distant from the US source makes HIFU an attractive option for development as a noninvasive surgical tool. In clinical application, our previous randomized phase II clinical trial indicated that HIFU is safe, effective, and feasible in the treatment of localized breast cancer.
Pathologic findings revealed that HIFU-treated tumor cells underwent complete coagulative necrosis, and tumor vascular vessels were severely damaged. Immunohistochemical staining showed that HIFU-treated tumor cells lost the abilities to proliferate, invade and metastasize. However, it is essential to evaluate the long-term clinical results of HIFU treatment for patients with breast cancer.
In this study we report our preliminary follow-up results of HIFU in the treatment of 22 patients with breast cancer, and assess a possibility of using HIFU as a potential breast conserving modality. The purpose of this study was to determine patient acceptance of this non-invasive procedure, post-HIFU tumor regression, follow-up pathologic changes, cosmesis, local recurrence, and survival in these subjects. It was not our intention to compare HIFU with conventional breastconserving therapies for patients with breast cancer.
Soft tissue Sarcoma.
Adult soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body.
The soft tissues of the body include the muscles, tendons (bands of fiber that connect muscles to bones), fat, blood vessels, lymph vessels, nerves, and tissues around joints. Adult soft tissue sarcomas can form almost anywhere in the body, but are most common in the legs, abdomen, arms, and trunk.
There are many types of soft tissue sarcoma. One type that forms in the wall of the stomach, intestines, or rectum is called a gastrointestinal stromal tumor (GIST). The cells of each type of sarcoma look different under a microscope, based on the type of soft tissue in which the cancer began.
Benign
Benign breast neoplasm.
A benign breast tumor is an area of abnormal cell growth in the breast which is not considered to be cancerous. A very high percentage of breast lumps turn out to be benign, meaning that they should cause few or no health problems to the owner of the breast, but all breast lumps should be examined by a doctor to check for malignancies. Monthly breast self exams are strongly recommended for all women, so that changes in the breast tissue can be detected as early as possible. Mammograms for cancer screening purposes are also recommended for older women.
Hepatic hemangioma.
Hepatic hemangiomas are thought to be present in as many as 7% of healthy people. Hemangiomas are four to six times more common in women than in men. Female hormones may promote the formation and growth of hemangiomas. Hemangiomas, although referred to as tumors, are not malignant and do not become cancerous. Hemangiomas are not unique to the liver and can occur almost anywhere in the body.
Uterine fibroids.
Uterine fibroids (non-cancerous tumors) are quite common - affecting between 20-50% of women of childbearing age. While many women do not experience any problems, symptoms can be severe enough to require treatment.
What are the key symptoms of uterine fibroids?
Heavy and prolonged periods
Bleeding between periods
Lower back or leg pain
Pain during sexual intercourse
Need for frequent urination caused by bladder pressure
Feeling of fullness in the lower abdomen
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