Keratoglobus is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to become extremely thin and change to a more globular shape than its normal gradual curve. It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye.
Inflammation is the first response of the immune system to infection or irritation and may be referred to as the Innate immune system and as healthy nor unhealthy on its own: Inflammation helps fight disease, but it comes at the cost of suspending the bodys normal immune and catabolic... A human eye. ... The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber, providing most of an eyes optical power. Together with the lens, the cornea refracts light and, as a result, helps the eye to focus. ... The Globular Cluster M80 in the constellation Scorpius is located about 28,000 light years from the Sun and contains hundreds of thousands of stars. ... In mathematics, the concept of a curve tries to capture the intuitive idea of a geometrical one-dimensional and continuous object. ...
It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea. Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and thirties. Keratoconus, is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape than its normal gradual curve. ... Dystrophy is any condition of abnormal development, usually due to malnutrition, especially denoting the degeneration of muscles (muscular dystrophy). ... Keratoconus (from Greek: kerato- horn, cornea; and konos cone), is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape than its normal gradual curve. ... American high school students Adolescence is the period of psychological, social, and physical transition between childhood and adulthood (gender-specific, manhood or womanhood).
Pathophysiology
Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print. It does not however lead to blindness per se. Blindness is the condition of lacking visual perception due to physiological or psychological factors.
Prognosis
Keratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. The patient is at risk for globe perforation because the thinned out cornea is extremely weak.
Surgical treatment
Further progression of the disease usually leads to a need for surgery because of extreme thinning of the cornea. Primarily, large size penetrating keratoplasty has been advocated. Recent additions of techniques specifically for keratoglobus include the "tuck procedure", whereby a 12 mm corneo-scleral donor graft is taken and trimmed at its outer edges. A host pocket is formed at the limbal margin and the donor tissue is "tucked" into the host pocket.
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